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The agency will continue to only use minors under 18 in compliance checks during a transition period.
Some states are delaying enforcement until the FDA finalizes regulations.
Retailers can still sell flavored e-liquids and disposable vapor products.
Twenty-six states implemented $1 or more increases as they rang in the new year.
Tobacco and menthol are not included in the new policy.
At least six lawsuits have been filed in federal court in Philadelphia.
Questions remain on how or when the agency will begin enforcing the change.
The change in the legal age to buy tobacco goes into effect in approximately nine months.
The association wants the FDA to clarify that it will not enforce the new age until it issues implementing regulations.
State and local officials wrap up the year with a slew of tobacco measures.
Tobacco issues dominated legislative agendas at all levels over the past 12 months.
The sale of all flavored tobacco products will be restricted to licensed smoking bars beginning June 1.
